Biosynthesis of fungal meroterpenoids
WebOct 26, 2015 · Biosynthesis of fungal meroterpenoids Y. Matsuda and I. Abe, Nat. Prod. Rep., 2016, 33, 26 DOI: 10.1039/C5NP00090D This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. … WebAug 1, 2010 · Among them, fungal meroterpenoids exhibit rich structural diversity with a wide range of biological activities 3 . In spite of their importance as potential therapeutic …
Biosynthesis of fungal meroterpenoids
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WebJo-Shu Chang, Xin-Qing Zhao, Jo‐Shu Chang, 2013, Bioresource technology. WebOct 1, 2024 · Fungal meroterpenoids are structurally diverse natural products with important biological activities. During their biosynthesis, α-ketoglutarate-dependent oxygenases (αKG-DOs) catalyze a wide range of chemically challenging transformation reactions, including desaturation, epoxidation, oxidative rearrangement, and …
WebJun 16, 2024 · The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide … WebWürzburg Area, Germany. • Served as lab expert on evolution of fungal sex and cryptic sexuality in the clinical isolates of the opportunistic fungal pathogen Aspergillus fumigatus. • Created ...
WebJan 2, 2024 · meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which were … WebFeb 27, 2024 · DMOA-derived fungal meroterpenoids possess complicated structures and attracted researchers’ attention to investigate the biosynthetic pathway. Some fungal …
WebThe biosyntheses of 9, 10, 25–28, and 32 provide important insights into fungal meroterpenoid pathways that generate their structural diversity: the same intermediate can be cyclized into different compounds, and furthermore, the same or highly similar scaffolds can be tailored in versatile manners. 2.3. Biosynthesis of 15-deoxyoxalicines
WebMay 3, 2024 · Based on their biosynthetic origins, meroterpenoids have been divided into two major groups: polyketide-terpenoids and non-polyketide-terpenoids. Non-polyketide terpenoids are further subdivided into three classes: nonribosomal peptide (NRPS)-terpenoids, terpenoid alkaloids, and meroterpenoid with unique structures. billy the exterminator season 3 episode guideWebNonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis This review summarizes the recent progress in research on the non-heme Fe(II)- and 2-oxoglutarate-dependent dioxygenases, which are involved in the biosynthesis of pharmaceutically important fungal meroterpenoids. cynthia forgie rate my professorWebMay 23, 2024 · Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive … billy the exterminator season 5 putlockersWebThe characterization of the biosynthetic gene cluster (BGC) pyr of meroterpenoid pyripyropene A accelerated biosynthetic studies on this family of NPs, which have solved many mysteries and... cynthia forkerWebDec 9, 2024 · Fungal meroterpenoids are secondary metabolites from mixed terpene-biosynthetic origins. Their intriguing chemical structural diversification and complexity, potential bioactivities, and … cynthia foristelWebJan 1, 2014 · The first gene involved in the biosynthesis of DMOA-derived meroterpenoids was identified in the genome database of Aspergillus nidulans FGSC A4, by the disruption of all of the PKS genes in A. nidulans [].The gene, designated as ausA, encodes a type I PKS that synthesizes 14 from one molecule of acetyl-CoA and three … cynthia forgueWebMeroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a … billy the exterminator season 3 watch free